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12 Comments

  1. Rhiannon Morgayne
    1 July 2013 @ 6:51 pm

    Unfortunately, only the now banned non-specific 5-HT receptor agonists like ergotamine work for me. That means I’m s.o.l. 🙁

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  2. Ravinder Johal
    2 July 2013 @ 6:53 am

    I have been taking a Triptan for years and this info has been very useful. Thank you!

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  3. Andrea Tamborello Sandberg
    2 July 2013 @ 12:34 pm

    #8 concerns me. I have to take my migraine medicine more than twice a month. Occasionally I have to take it 2 times in 1 day, but I know I can’t go over that in a 24 hr. period. I’ll have to talk to my doctor about this next time I see him.

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  4. Janet
    6 July 2013 @ 4:29 pm

    James, thanks for this. Could you write more about the need to get eyes checked? I have not heard that before.
    Regarding changing triptans I can vouch for that. I took Imitrex when it first came out, switched to Zomig after Imitrex became less effective for me, probably stayed on it too long, and a few years ago changed to Axert, which works fairly well for now.

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  5. Agnes
    8 July 2013 @ 7:21 pm

    Dear James,
    Your warning about long-term use is a wake-up call, as is your advice on using triptans as part of a treatment plan. I have been using Imigran since 2001 at the rate of 1 50 mg tablet per 2 weeks and it works mostly very well for me.
    As a side effect I have an increased heat sensitivity, as when washing hands in warm water or drinking tea. Is there an explanation for this and have others experienced it?
    My other issue is with habituation. My migraines were linked to the hormone cycle. A friend of mine and my mother had the same trigger, but never took triptans and their migraines disappeared in menopause. I have been menopausal for 10 years, yet I still get the tell-tale signs and if I at times challenge my system and not take the Imigran, or take it too late, I do get the pains, the nausea, the vomiting. Has the involved neurotransmitter biochemistry become lazy and dependent on the triptan?

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    • Teren
      21 September 2013 @ 4:30 pm

      I don’t take triptans as often as some, perhaps 10 in the past 18 months, but last time I experience intense heat sensitivity in my hands. It was spooky! Tepid water felt as thought it was scalding my hands and they turned bright red. I plunged them in cold water and they immediately returned to normal. Tried it again and the same experience repeated. My doc doesn’t believe it’s related to the triptan (tho’ she’s not ruling it out), but I KNOW it had to be that.

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  6. donna
    23 December 2013 @ 3:50 am

    The heat sensitivity is from the medication. I get the same symptom. What I didn’t know was that some people didn’t get that reaction.

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  7. Agnes
    23 December 2013 @ 4:02 pm

    Teren, scalding is the right word. I always make my cup of tea the same old way, but an hour or so after taking Imigran, when I have the first sip, it always feels as if I’m burning my mouth. I would love to know the cause. Any biochemist out there, who can give an explanation ?

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  8. Helen Harvey
    22 February 2014 @ 6:14 pm

    I’ve been taking Naratriptan 2.5mg for migraine for the past 5 yrs as treatment (as and when have an attack). I also take on a daily basis Propranolol 40mg (2 to be taken twice a day) and if nec. I have Imigran 10mg (which I’ve yet to use). The treatment regime I have works for me. The longest gap between attacks for me is 8 Nov ’13 – 08 Feb ’14 (93 days).

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  9. Antidepressants, Migraine, Triptans and Serotonin Syndrome: Should You Be Worried? - black dog pie: a magazine on depression and bipolar
    26 May 2014 @ 3:29 pm

    […] Read more … […]

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  10. Deborah McGhie
    16 May 2016 @ 9:00 pm

    I’ve suffered with debilitating migraines for more than 25 years now. Ive tried every prophylactic drug in the book, even the top dose of Topamax and Botox injected into my head did nothing.

    When I first came across Zomig and Imigran it changed my life. But, unfortunately, they brought a new problem with them. Rather than getting rid of the migraine, Zomig and Imigran postpone it. For about 24 hours. Literally 24 hours later it just comes back. It has been like this for over 10 years now. Which means I have to take 5mg every day in order to just be normal. My doctor is not happy that I’m doing this but, as I told her, I need quality of life. Without sumatriptans, I get sucked into a cycle of severe migraines with projectile vomiting that take me over a week to recover from, leaving me weak and crushed.

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