Comments on: ADX10059 – another Migraine Drug in the Pipeline http://headacheandmigrainenews.com/adx10059-another-drug-in-the-pipeline/ Thoughts and information about the latest news in the world of migraine, cluster headache and other headache treatment around the world. Mon, 06 Feb 2012 17:36:29 +0000 hourly 1 http://wordpress.org/?v=3.1.3 By: Tom http://headacheandmigrainenews.com/adx10059-another-drug-in-the-pipeline/comment-page-1/#comment-47259 Tom Tue, 19 Jan 2010 00:37:52 +0000 http://headacheandmigrainenews.com/adx10059-another-drug-in-the-pipeline/#comment-47259 Addex to end development of the long-term use of ADX10059. In our Phase IIa clinical trial in 129 migraine patients, significantly more of the patients who received ADX10059 than those who received placebo were pain-free two hours after dosing (see Fig. 4). ADX10059 had better pain improvement than placebo at all time points up to two hours. The results of the study suggest that mGluR5 inhibition might play a role in migraine therapy. As a result Addex conducted further studies in migraine prevention to establish whether the compound has a role in this indication. However, data from study 206, a 3-month study in migraine, have shown liver toxicity and led Addex to end development of the long-term use of ADX10059. Addex to end development of the long-term use of ADX10059.

In our Phase IIa clinical trial in 129 migraine patients, significantly more of the patients who received ADX10059 than those who received placebo were pain-free two hours after dosing (see Fig. 4). ADX10059 had better pain improvement than placebo at all time points up to two hours.

The results of the study suggest that mGluR5 inhibition might play a role in migraine therapy. As a result Addex conducted further studies in migraine prevention to establish whether the compound has a role in this indication. However, data from study 206, a 3-month study in migraine, have shown liver toxicity and led Addex to end development of the long-term use of ADX10059.

]]> By: James http://headacheandmigrainenews.com/adx10059-another-drug-in-the-pipeline/comment-page-1/#comment-6849 James Fri, 10 Apr 2009 12:25:54 +0000 http://headacheandmigrainenews.com/adx10059-another-drug-in-the-pipeline/#comment-6849 I really do think we're heading into a new era of migraine treatment. Not quite there yet, but things are moving along! I really do think we’re heading into a new era of migraine treatment. Not quite there yet, but things are moving along!

]]> By: Megan Oltman http://headacheandmigrainenews.com/adx10059-another-drug-in-the-pipeline/comment-page-1/#comment-6014 Megan Oltman Tue, 31 Mar 2009 15:43:39 +0000 http://headacheandmigrainenews.com/adx10059-another-drug-in-the-pipeline/#comment-6014 Thanks for the heads' up James - great to know about the new drugs - they sound like they have a lot of potential. Thanks for the heads’ up James – great to know about the new drugs – they sound like they have a lot of potential.

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