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33 Comments

  1. Mary Kay
    9 October 2008 @ 10:04 am

    Great review of Splenda. I can tell you that in my practice, aspartame is a known trigger for migraine. I haven’t heard about Splenda causing the problem, but then perhaps I need to ask more about it!

    As always, food triggers are something we can control for migraine and it is not as common as stress, hormomes or weather changes (in that order).

    Hmmm…more “food for thought” about migraine (ha!)

    Reply

  2. Diana Lee
    13 October 2008 @ 7:56 pm

    I don’t know for sure that Splenda and other artificial sweeteners are triggers for me, but I try to avoid them as much as possible because I suspect they are. It’s just not worth it to me to consume them.

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  3. James
    15 October 2008 @ 12:27 pm

    Yes, more food for thought indeed! It’s been very interesting hearing comments on this one. I agree, Diana – not worth it to take the risk.

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  4. Suzie
    16 October 2008 @ 2:27 pm

    My step-father is a diabetic and I was consistently getting a migraine after visiting my mother and step-father until I realized that the drinks my mother was offering me were “diet” tea or lemonade and many of the desserts she makes are made with Splenda.

    I have seen a very defined cause-and-effect pattern of migraine when consuming anything with artificial sweeteners. I avoid them like the plague now.

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  5. James
    22 October 2008 @ 6:56 am

    Yes, I personally tend to avoid them too, Suzie. Thanks for the comment!

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  6. Tom
    4 December 2008 @ 2:02 pm

    I get headaches from Splenda-sweetened products every single time I consume them. Consequently, I avoid Splenda like the plage. I wholeheartedly agree that there should be more research into potential adverse effects. Despite assertions to the contrary from those advocating Splenda, I don’t see how it is definitive that Splenda is non-allergenic. Certainly, Splenda-related headaches could be partially explained if they were side-effects from allergic reactions.

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  7. James
    8 December 2008 @ 5:49 pm

    Yes, that’s exactly right, Tom. Too often people get away with saying,”It’s just not proved”. That’s not the same as saying,”We’ve proved beyond reasonable doubt”.

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  8. Yadi
    23 February 2009 @ 6:47 pm

    I’ve been getting migraines for over 20 years. I started using Splenda about 3 years ago. I only recently realized that it coincided with 3 years of the worst migraines I’d ever experienced. I was in the ER every 3 to 4 months. A friend suggested I stop using Splenda and its like magic!! Am I headache free? No. However, I stopped using Splenda 2 months ago and I feel like my life is no longer consumed by pain.

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  9. Get involved – share your opinion!
    17 August 2009 @ 8:59 am

    […] Comments – you all knew about this one, right?  Be sure to leave your comments right here, on the topic of each post!  Anything that interests you is open, but here are some posts that have had some conversation going – Topamax may cause language disturbances, Demerol for Migraine in the Emergency room, What is Migraine? (The Life Impact Story) and Splenda and Migraine revisited […]

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  10. Christine
    17 August 2009 @ 5:39 pm

    I’ve been using Spenda for the past couple of years, and I have also had many fewer migraines (possibly because I also started Pamelor and switched to Seasonique). Maybe I would have had none at all without the Splenda, but the only way to know is to switch to aspartame, because I am not giving up my 2 diet colas a day (a woman has to have some vices). I trust aspartame less than I do Splenda. When they come out with a reasonably-priced diet cola with Stevia, I will definitely try it.

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  11. Jennifer
    12 October 2009 @ 11:08 am

    Aspartame is the worst possible alternative to sugar I know! I got horrible migraines, light headedness, dizzy, etc. I’m wondering now if Splenda is doing the same…*sigh* I like soda…but I have medical history in my family of diabetes. So…I can’t drink the regular soda. So now what?

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  12. Carolyn
    27 April 2010 @ 8:43 am

    I’m sorry but for anyone suffering from Aspartame or Splenda toxicity and is a diabetic, sodas are just out of the question. Just drink fizzy water with a spash of fresh lime. I switched a few years ago after Aspartame made me severly ill for over a year, and I haven’t looked back since.

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  13. David
    27 April 2010 @ 9:59 am

    I don’t get migraines, but I have noticed that I often get headaches when I drink my morning coffee sweetened with Splenda. On the other hand, I also eat blueberries and milk sweetened with Splenda, and don’t recall getting a headache from that.

    The headaches aren’t bad, but I’ll definitely be watching to see if there is a consistent pattern. I’m relatively headache free, so I noticed when they started. They seemed to be connected to Splenda, and a Google search led me here.

    Reply

  14. Betsy
    5 May 2010 @ 11:24 am

    I’m in the process of determining whether switching from aspartame to Splenda has been the cause of the last 4-5 years of increased migraine frequency for me. During that time, I’ve had periods of status migrainosus lasting from 3 weeks to 1 1/2 years (!!!). My “normal” frequency has become 4-5 migraines a week! No neurologist has been able to find a preventative drug regimen that will work for me, since my trigger is changes in weather. Finally, my neuro’s PA suggested I give up ALL artificial sweeteners – she wondered if maybe that was what was pushing my migraines so close to the edge that just a slight change in barometric pressure would result in a migraine. Since I really don’t want to move to another area of the country, it sure seemed worth a try…

    I typically drank a whole pot of decaf with 11 Splenda in it, plus 2 quarts of a non-carbonated soft drink containing Splenda.

    Mind you, it’s too early to tell for sure, but I’m now free of any artificial sweeteners for 3 weeks and have been migraine-free for almost 2 weeks…(Man – I hope I didn’t just jinx myself!)

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  15. Robin
    12 August 2010 @ 3:25 pm

    Not so sure,but I drank 2 cups of coffee yesterday with splenda and I never use artificial sweetener. About 2 hours later I ended up with a migraine and have had it ever since. Usually my triggers are lack of sleep and stress so it was odd to get this one out the blue since I was feeling pretty good. I know it was the splenda so I’m sticking to sugar.

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  16. Susan
    16 August 2010 @ 5:05 pm

    Splenda is bad stuff; so are all of the other sugar substitutes. Mannitol, sorbitol, aspartame, saccharin; they all cause migraine. Most artificial ingredients do. Calcium chloride is just as bad as MSG. Drink lots of water to clear it out of your system and stick with all natural foods. Even most chewing gums have one or more artificial sweeteners. Look for Glee Gum at a health food store!

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  17. Adriana
    27 January 2011 @ 1:41 pm

    My trainer suggested I mix my protein powder with G2 gatorade which has sucralose. I have been doing this for about 3 weeks now and this week my migraines started up again. It has been a very long time since I have one…I am having them everyday. I eat very healthy and natural due to that I’m gluten free and that is the only change in my diet. I believe the sucralose must have triggered them again….not happy!

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  18. CARRIE
    2 June 2011 @ 9:53 am

    I have been suffering from chronic headaches for about a month now…..Tried several migraine medications prescibed by my dr. to no avale. I finally figured out what changed a month ago…..I had started drinking quite a bit of sparkling water that was full of sucralose. Stopped drinking it completely and went back to drinking plain ole’ water and an occasional 7-up as treat. The migraines have miraculously disappeared. Maybe this artificial sweetner is fine for some people….but I do believe it is a migraine trigger for some like me. I am just glad that I figured it out and got some relief. I will never again eat or drink anything with sucralose in it!

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  19. MB
    18 February 2012 @ 7:44 am

    I was drinking 3 large cans Arizona green tea with Splenda /day. Suddenly 5 out of 7 past days I have developed severe migraines with aura. I have been thoroughly checked out and everything points to Splenda intake. I am cutting it out and hoping it will help.

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  20. Joie
    4 April 2012 @ 5:12 am

    I was diagnosed with severe clustral migrianes in nov 2011. I have found that one of the triggers are artificial sweetners. This limits what I can drink due to the fact I have been diagnosed diabetic in Feb 2012. I am also on anti seizure medications to help treat these horrid migraines but I still get them, and I have clear mri’s and cat scans. So yes I do believe that these sweeteners that are slightly better for you are actually worse for people.

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  21. Debby K.
    21 May 2012 @ 1:36 pm

    I tried the new V8 juice blend with splenda when it first came out, and had killer migraines within 15-20 min. I tested it a number of times to confirm that it was really the splenda causing the migraines, and it was. I have non-life threatening allergies to many chemicals, chlorine bleach being one, so that connection may be the cause of the trigger, but I read all labels now. Recently I used some mouthwash at church without checking the ingredients beforehand, and within 10 minutes had a migraine due to the splenda in the mouthwash. Its widespread use really frightenens me, especially as its now being hidden in ingredient listings under various labels of sugar blends.

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  22. kp
    25 September 2012 @ 11:54 pm

    I have a sister-in-law who is actually allergic to aspartame. In addition to digestive upset, she gets facial and mouth swelling after eating/drinking/using products that include aspartame and similar sweeteners- including Splenda. Personally, I am recovering form a three-day-straight migraine headache after drinking a bottle of juice that I didn’t realize was sweetened with Splenda.

    I’m gonna stick with my natural cane sugar, thanks.

    Reply

  23. Jerry
    1 October 2012 @ 4:31 pm

    I am doing my own study right now (on myself). I have noticed that when I have a lot of Splenda during a day, I often end up with a headache (migraine?) that evening or wake up with one the next morning. I had about 10 glasses of (Splenda) sweet tea yesterday and had a slight headache last night and this morning. For the next week, I will avoid Splenda 100% and see if I have any headachs.

    Reply

  24. L.G.N.
    19 October 2012 @ 12:41 pm

    Most beverages in the market have been giving me headaches and migraines the last few months. I realized they changed from glucose to splenda. I started to try different soda pops, teas and fruit juices, and so far everything with Sucralose and maltodextrine or Splenda(the brand name in the label) gives me migraine. Corn syrup of high fructose, and other kinds of corn syrup give me mild headaches, almost always but not always, specially in high concentrations (i.e. 90 grams of sugars per 250 ml). Regular coke seems the only bottled beverage i can have without problems until the third glass, but that might be ’cause its relatively low content of sugars. I think i will just abstain of synthetic sweeteners, as many others will, but I hope they further research splenda, since is becoming very common in the food industry.

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  25. Steven
    8 May 2014 @ 1:26 pm

    Everytime I use Splenda I get a migraine headache. I noticed it when i would go to my moms house and drink her tea. at the time I couldn’t figure out why I was getting headaches. then one day at work I drink a Gatorade that had Splenda and what would you know migraine headache.

    Reply

  26. Yvette
    28 May 2014 @ 1:24 pm

    Over the past few days I have been suffering from horrible headaches. I do suffer from allergy/sinus headaches on occassion, but these headaches felt different (dizziness, tenderness in my temples). I have been trying to figure out why I’m feeling this way all of a sudden. Then it hit me…last week I accidentally purchased sugar free ice cream made with Splenda. I rarely use artificial sweeteners, and that is the only new item in our household. I also made the connection that the days after I did not eat the ice cream, I felt much better. Needless to say, I threw the rest out and I’m hoping to detox and feel better very soon.

    Reply

  27. Natasha
    3 July 2014 @ 6:56 am

    I thought I would list some of my other migraine triggers to maybe help others.
    ALL artificial sweeteners (I am also very sensitive to sugar alcohols–but it is digestive issues)
    Too much soy
    Certain artificial food colorings–I’m not sure which ones exactly because they tend to come in groups. I avoid red 40, blue 1, blue 2, yellow 5, and yellow 6 to be safe.
    Strong smells–especially floral, perfume, or synthetic fragrances–this one really gets me. It can be something as simple as fresh cut grass or a fire. I can’t use scented deodorant or laundry detergent. I can handle fruity or foodie scented things much better. Natural lavender doesn’t usually bother me. Since I cut out most triggers, I mainly get migraines induced by some smell. I used to get 3-5 crippling migraines a week. Now I get 1 or 2 every month or so. Sometimes because of sneaky Splenda in everything–I even saw it in pain medicine the other day.

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  28. evan penn
    20 August 2014 @ 8:51 pm

    I am suffering at this very moment from migraine-type headache. I woke up this morning with it. It is now 9:45 at night, and it seems to be lessening. I tried to think of anything I did differently yesterday, as I am careful about triggers from food. I realized I’d drank a few glasses of an iced tea with Sucralose, when I was at my parent’s home. It was “Zero Calorie” which made me look on the label. Normally I wouldn’t eat or drink diet foods. My parents don’t consume “diet” foods either, as they also think they are not good for you, but my Mom had purchased this product by mistake. I am, obviously, not sure the Sucralose was the trigger, but the severity of this migraine was extremely rare for me. The consumption of Sucralose is likewise extremely rare for me as I can’t recall the last time I ate or drank something “diet”. Just my personal anecdote. I will, from this point forward, avoid it at any costs.

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  29. Amy
    30 November 2014 @ 5:37 pm

    I can definitely say that Splenda is a trigger for my migraines. It happened 3x now – in a row. Had the oyher foods with it before (all my life) with no problems. I suppose it may depend on the type of migraine you get – vascular vs oculat vs cluster etc – what triggers are common with each (based on the mechanism). My husband was just diagnosed as diabetic and we’ve tried Splenda as a sugar substitute for BOTH of us, so I don’t tempt him. That’s when I distictly got these 3 successive migraines. Splenda was the only difference. I doubt the manufacturer will do any real studies to conclude this because they want marketshare.

    Reply

    • Natasha
      2 December 2014 @ 3:26 pm

      So far I have had no issues with Stevia. Don’t be foiled by Truvia. Look for Sweet Leaf. They even have flavor drops you can use.

      Reply

  30. Andrea
    22 April 2015 @ 8:51 pm

    The trigger for me is the dextrose used in the Splenda packets (as a filler/volumizer). I can consume sucralose as long as it didn’t originate in the packets.
    Dextrose is used on flavored chips, in pudding, crescent rolls, so many things I can’t name them all. My headaches almost completely disappeared when I started to read the ingredient lists for EVERYTHING I eat and stopped eating dextrose.

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  31. Sarah Beth
    2 October 2016 @ 12:57 am

    I get HORRIBLE headaches whenever I have sucralose! I thought I was the only one!

    I wonder of it has to do with the type of chlorine, I have a bad reaction to bleach & pools.

    I hate that they’re sneaking sucralose in products, along with high fructose corn syrup. Pick one or the other!!!

    With some Arizona Beverages, some sweetened drinks, and even cough syrup (?!?) I assume they’re sucralose free- it doesn’t say “diet” anywhere on it, then eat or drink it, then get a pounding headache, then check the ingredients, and, sure enough, sucralose.

    When will they learn that for some people, “diet” does NOT mean “healthy”?!?!

    Reply

  32. Rebecca Mitovich
    17 October 2020 @ 4:21 am

    It’s the middle of the night and I am sitting here nursing a two day horrible migraine! The constant pain is exhausting and as I was in the kitchen putting some Splenda in a cup of regular coffee, which dulls the pain for me, I realized that it could be the cause. Eureka! I had made some diabetic desserts for my brother using it,and of course had to test everything, and have been suffering over the last 36 hours! I am going to eliminate my sweetener altogether and do my own study. Will let you know the results. Thank you for this site.

    Reply

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