Back in 2008 we talked about some unique nasal sprays that were being tested for migraine treatment. One of these was AZ-001, a nasal spray using the drug prochlorperazine.
I’m not sure if that specific version is being actively developed by Alexza Pharmaceuticals or not, but the concept is still being researched. Dr. Venkata Yellepeddi from Roseman University of Health Sciences has developed a nasal spray based on prochlorperazine. Here’s what he had to say:
Prochloperazine is a dopamine receptor antagonist that is widely used as an anti-nausea medication. Comparative clinical studies have shown that prochloperazine provides better pain relief than other anti-migraine drugs such as sumatriptan, metoclopramide, and ketorolac. Currently, there are no marketed nasal spray formulations of prochlorperazine available for the treatment of migraine. Prochlorperazine is only available in tablet form, which has delayed onset of action.
Prochlorperazine is already used for migraine, and is especially useful for migraine with nausea. It’s also used for severe nausea from other causes, and in some cases as a antipsychotic. It’s sold under brand names such as Compazine, , and Buccastem among others.
Nasal sprays are useful for a number of reasons. For one thing, by bypassing the gut they are more useful for patients with nausea. A more precise amount of medication will get into your system, and will be available faster.
Dr. Yellepeddi has also created a nasal spray with no preservatives, which may cause problems in some patients. The formulation seems to be stable, but unfortunately testing is still in the early stages. We may have to wait several more years before this one is available.
For more, read the press release from the American Association of Pharmaceutical Scientists: First-in-class nasal spray demonstrates promise for migraine pain relief