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8 Comments

  1. Jon
    23 November 2014 @ 9:52 pm

    I’m very interested in this as an alternative. My wife is currently taking indomethacin for a diagnosis of hemicrania continua, but its seems to only be moderating the pain – she’s not experienced the relief that it sounds like most people achieve. Sometimes it appears that she’s not getting relief at all.

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  2. John
    21 August 2015 @ 8:57 am

    I suffered a lot from HC, used indomethacin for years successfully.
    Suddenly it didn’t work anymore. I came to melatonin by studying internet. From the first (even low ) dose it was successfull!
    At the end I need 3 mg daily as a tablet or 1 mg as melting in the mouth tablet. The latter is best because of the better bio availability.
    I am free of HC for years now, with only melatonin.

    Greet, John (the Netherlands)

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  3. Gillian Griffiths
    24 September 2015 @ 4:44 pm

    John from Netherlands
    I am so glad for you. I have been given Melatonin today….. Hope I get some relief like you.

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  4. John
    25 September 2015 @ 1:23 pm

    Dear Gillian,
    Thanks for your nice reply. I really hope it works for you as well.
    It may be interested to add that the chemical structures of Indomethacin and Melatonin have a lot in common. This might explain why these substances are both of interest for HC patients.

    Greet, John

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  5. chris
    11 July 2016 @ 9:19 am

    Hi
    I have HC had it for 5 years (since diagnosis) i was taking indomethacin which was a instant relief from the head aches but about 3 years ago i was diagnosed as being type 2 diabetic and was taken of indomethacin immediately by my GP. I was then put on co-dydromol which sometimes i can take up to 10 a day, problem with co-dydramol is it only deals with the pain once tablets have been taken i.e. upto 30 mins to work, with indomethacin i didn’t have a headache for 2 years ( what a relief). I do suffer during the night with waking up with head aches also sometimes the pain gets so intense i vomit there is not a day goes by without pain, i have just come across this web site and seen this other medication I’m going to book a appointment with my GP to see if i can safely take this being diabetic and will keep this web site posted with the out come.

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  6. John C
    26 May 2017 @ 1:07 pm

    Hi I have had HC now for almost two years, i was on indomethacin, was told could not take for long time cause it might cause stomach problems , I took it for two months , doctor wanted to increase dosage
    I said no. been trying other meds they have given me ,Zero.
    But a aspirin will take care of it for a while, But they too much aspirin is not good either.
    I did try melanotin once did not think it was helping. I am going to try again , they had me take at bedtime , think I’ll take in morning
    by the way indomethacin did work. thanks for listening.

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  7. Julie
    21 June 2018 @ 3:31 am

    Hi I’m taking naproxen 250 mg for hemacranial for a month now still have the burning sensation on left side of head , does the melatonin interfere with blood pressure medication

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  8. Wayne Patrick Salter
    23 October 2021 @ 6:44 pm

    I was not diagnosed by 2 neurologists and then my wife after 27 months, investigated 24\7 migraine and I told Dr. to prescribe Indomethacin and 26 months later, after one dose the headache diminished and then first time without pain that often became excruciating.

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