The latest migraine Topamax study was published in Pediatrics this month. It was a study of migraine patients age 12-17.
The children and teen crowd have had far fewer migraine studies done. Last year we talked about Topamax for children; this study focused on the older subset – adolescents. Here’s what they found:
As you can see, there was a significant difference. In more practical terms, those taking Topamax went from 4.3 attacks per month to 1.3, and had fewer days with migraine. (Note, however, that even those on a placebo saw a significant reduction in attacks, so the numbers aren’t quite as good as they look) The numbers on the bottom of the chart show percentages.
The researchers said that topiramate was well tolerated. However, the fact of the matter is that almost 3/4 of the patients experienced side effects. The common ones were upper respiratory tract infection, itchy or tingling skin, and dizziness.
There should be some concern that, in the rush to make Topamax an "approved" migraine drug around the world, we start thinking it’s the best thing to try. The fact remains that topiramate is a powerful drug which commonly has side effects. It is hoped that Topamax will not be the first thing your doctor recommends.
This is especially important in children. As was pointed out in the Italian review in 2008, we should be especially concerned about the impact these side effects will have on children and teens. Other common side effects in children are weight loss, anorexia, trouble concentrating, and tiredness.
Topamax may prove to help adolescents with migraine. However, the side effects may prompt many to look at other options.
Via: Topiramate safely prevents migraine in adolescents
Popularity: 24% [?]
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{ 2 comments… read them below or add one }
Hi James,
I am going to respectfully disagree with your post. Topamax is a wonderful drug for severe migraineurs and is not considered “powerful” but therapeutic. Side effects many times wear off after a few months of treatment and compared to severe pain, nausea and vomiting they are acceptable to most people.
I have prescribed this drug for over 10,000 people and was told recently I am one of the top 50 prescribers for it in the US..I have also done research on it. (I have no affiliation with the company!)
It IS the best thing to try because the response rate for migraine is so high..it is my treatment of choice with a new patient..including teens and I have used it there for years.
You can edit this if you like, but remember how many people read your blog..strong statements about treatment are best left to headache practitioners. Many migraineurs have high anxiety and reading this will cause them to stop the drug..if they do it suddenly they run the risk of causing a seizure due to abrupt withdrawl.
Thanks for the update from Pediatrics..
Thanks, Mary Kay,
Don’t worry, I’m not in the habit of “editing” my visitor’s comments!
First of all, don’t misunderstand what I’m saying. I am not suggesting that topiramate is an unwise choice for everyone. It has helped many people – I’ve said that before, and I’ll say it again. Every drug has its pros and cons – topiramate is the same.
We may differ on what we mean by the “best” thing to try. Is it the “best” thing to try for everyone? Certainly not. Other practitioners would agree with that (for example, Dr. Carolyn Berstein in her book The Migraine Brain suggests that it be tried on patients that have tried other medications without success).
There are many patients who have had a great deal of success without drugs, for example. Would topiramate be the best treatment to try, or the best drug? Either way, there are clearly experienced practitioners who would disagree with you (or with me!).
The side effects of topiramate are well known. For example, Drs Silberstein and Young in their book Migraine and Other Headaches write about several of the side effects of topiramate, then point out that these side effects usually go away after the patient stops taking the drug. Usually?
Clearly, being one of the top prescribers of topiramate in the US, you’re convinced of your opinion. That’s not a bad thing. I appreciate that you’ve done your research, and that you’re speaking out of experience, and the desire to help your patients.
But to say it’s the best thing to try is a very debatable statement. Even if it’s true, it is not true for everyone.
My point was that we need to consider very carefully before we say something is the best thing to try. Consider lifestyle changes, supplements, non-drug treatments, and other drugs (that may give you fewer side effects). Consider the medical history of the patient, what other drugs and treatments are being taken, and what symptoms are predominant.
My concern is that many people are not considering the pros and cons, and are not being properly informed by their practitioners.
Of course, I’m sure that’s not you, and I’m not suggesting that. But people need to be informed and make decisions based on the facts.
Finally, regarding leaving “strong statements about treatment” to headache practitioners. I believe my statements have been balanced here and in the past. I have said that topiramate has helped many, and I’ve also said that there are concerns about it. These are concerns coming from doctors, researchers, and patients, not just from me.
Every one of us has a part in fighting migraine and other headaches. We should be very careful about excluding people from the conversation.
I am very glad to have your comments – and the comments of anyone who disagrees. This is a conversation, and none of us have the whole story. We should be careful about what we say, but we need to call it as we see it.
As you disagreed with my statement that it shouldn’t be the first thing your doctor recommends, I disagree with your statement that it’s the best thing to try.
That being said, I want to agree with and re-emphasize your point that someone already taking topiramate should not suddenly go off it. As I have said over and over, any changes in medication need to be discussed with your doctor.
The question of this post is not whether you should stop it suddenly, but what those involved in the treatment of adolescents and children need to consider.
Thanks again for your viewpoint, and for reminding everyone of that last point.